Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study

• DOI: 10.1186/s13023-015-0263-4
• Publication Date: 2015-04-21T06:47:38Z
• Authors: Adrian Baican; Roxana Chiorean; Daniel Corneliu L...; Corina Baican; Sorina Danescu; Dorina Ciuce; Cassian Sitaru
• Keywords: Pemphigus foliaceus; Pemphigus vulgaris

Factors associated with survival in pemphigus have not yet been thoroughly addressed. Therefore, the present study, risk factors for overall mortality a large group of patients vulgaris and foliaceus were investigated. A retrospective hospital-based cohort study was carried out, between October 1998 November 2012, Department Dermatology University Medicine Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. The investigated prognostic endpoint patients. total 130 studied (108 22 foliaceus). In group, univariate analysis found statistically significant association age onset ≥ 65 years (p < 0.001), presence coronary heart disease = 0.006), cardiac arrhythmia 0.004), level anti-desmoglein1 autoantibodies 100 U/mL 0.047) at diagnosis An age-adjusted showed results disease. Multivariate identified as independent mortality. foliaceus, 0.021) poor survival. addition to common factors, including older cardiovascular comorbidities, be disease-specific factor vulgaris. newly major implications stratification should greatly facilitate further epidemiological studies pemphigus. addition, they provide useful information design personalized therapeutic plans clinical setting.