Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL

• DOI: 10.1186/s13045-022-01333-0
• Publication Date: 2022-08-26T15:03:31Z
• Authors: Darko Antic; Natasa Milic; Thomas Chatzikons...; Lydia Scarfò; Vladimir Otasevic; Nina Rajovic; David Allsup; Alejandro Alonso ...; Martin Andres; Monica Baile Gonz...; Antonella Capasso; Rosa Collado; Raul Cordoba; Carolina Cuéllar-...; Juan Gonzalo Correa; Lorenzo De Paoli; Maria Rosaria De ...; Giovanni Del Poeta; Maria Dimou; Michael Doubek; Maria Efstathopoulou; Shaimaa El-Ashwah; Alicia Enrico; Blanca Espinet; Lucia Farina; Angela Ferrari; Myriam Foglietta; Alberto Lopez-Garcia; José A. García-Marco; Rocío García-Serra; Massimo Gentile; Eva Gimeno; Maria Gomes da Silva; Odit Gutwein; Yervand K. Hakobyan; Yair Herishanu; José Ángel Hernán...; Tobias Herold; Gilad Itchaki; Ozren Jaksic; Ann Janssens; Olga B. Kalashnikova; Elżbieta Kalicińska; Arnon P. Kater; Sabina Kersting; Maya Koren-Michowitz; Jorge Labrador; Deepesh Lad; Luca Laurenti; Alberto Fresa; Mark-David Levin; Carlota Mayor Bas...; Lara Malerba; Roberto Marasca; Monia Marchetti; Juan Marquet; Biljana Mihaljevic; Ivana Milosevic; Fatima Mirás; Marta Morawska; Marina Motta; Talha Munir; Roberta Murru; Raquel Nunes; Jacopo Olivieri; Miguel Arturo Pav...; Inga Piskunova; Viola Maria Popov; Francesca Maria Q...; Giulia Quaresmini; Gianluigi Reda; Gian Matteo Rigolin; Amit Shrestha; Martin Šimkovič; Svetlana Smirnova; Martin Špaček; Paolo Sportoletti; Oana Stanca; Niki Stavroyianni; Doreen Te Raa; Kristina Tomic; Sanne Tonino; Livio Trentin; Ellen Van Der Spek; Michel van Gelder; Marzia Varettoni; Andrea Visentin; Candida Vitale; Vojin Vukovic; Ewa Wasik-Szczepanek; Tomasz Wróbel; Lucrecia Yáñez Sa...; Mohamed Yassin; Marta Coscia; Alessandro Rambaldi; Emili Montserrat; Robin Foà; Antonio Cuneo; Marc Carrier; Paolo Ghia; Kostas Stamatopoulos
• Keywords: Hematology

Abstract Background Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due the advanced age, presence of comorbidities, disease treatment-related immune deficiency. The aim this study was assess risk bleeding in patients CLL affected by severe COVID-19. Methods This is a retrospective multicenter conducted ERIC, European Research Initiative on CLL, from 79 centers across 22 countries. Data collection between April May 2021. diagnosis confirmed real-time polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 nasal or pharyngeal swabs. Severe cases were defined hospitalization need oxygen admission into ICU. Development type thrombotic events, severity complications reported during treatment Bleeding events classified using ISTH definition. STROBE recommendations used order enhance reporting. Results A total 793 included 593 being hospitalized (74.8%). Among these, 511 as having COVID: 162 admitted ICU while 349 received supplementation outside Most (90.5%) receiving thromboprophylaxis. During treatment, 11.1% developed thromboembolic event, 5.0% experienced bleeding. Thrombosis 21.6% who not thromboprophylaxis, contrast 10.6% episodes frequent intermediate/therapeutic versus prophylactic doses low-molecular-weight heparin (LWMH) (8.1% vs. 3.8%, respectively) elderly. In multivariate analysis, peak D-dimer level C-reactive protein albumin ratio prognostic factors occurrence (OR = 1.022, 95%CI 1.007‒1.038 OR 1.025, 1.001‒1.051, respectively), thromboprophylaxis use protective 0.199, 0.061‒0.645). Age LMWH dose administration model 1.062, 1.017–1.109 2.438, 1.023–5.813, respectively). Conclusions are at high if used, but also increased under administration.