UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy

• DOI: 10.1186/s13046-016-0308-0
• Publication Date: 2016-02-16T23:16:41Z
• Authors: Xuechao Wan; Shu Yang; Wenhua Huang; Denglong Wu; Hongbing Chen; Ming Wu; Junliang Li; Tao Li; Yao Li
• Keywords: Biochemical recurrence

Biochemical recurrence (BCR) is widely used to define the treatment success and make decisions on if or how initiate a secondary therapy, but uniform criteria BCR after radical prostatectomy (RP) not yet completely assessed. UHRF1 has unique function in regulating epigenome by linking DNA methylation with histone marks. The clinical value of PCa been well done. Therefore, we evaluated prognostic significance UHRF1. expression cells was monitored qRT-PCR Western blot analyses. knocked down using specific siRNAs, effects knockdown proliferation, migration, cell cycle, apoptosis lines were investigated. protein 225 specimens immunohistochemistry tissue microarrays. Correlations between features results showed that overexpressed almost all lines. In cells, inhibited proliferation induced apoptosis. levels correlated some PCa. Multivariate analysis an independent factor for biochemical recurrence-free survival. functions as oncogene prostate cancer appears be capable predicting risk patients prostatectomy, may serve potential therapeutic target