IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis

• DOI: 10.1186/s13046-024-02970-8
• Publication Date: 2024-02-12T02:23:47Z
• Authors: Kaifan Yang; Yanjun Hu; Yuanyuan Feng; Kaiqun Li; Ziyan Zhu; Shuyi Liu; Yanling Lin; Bin Yu
• Keywords: Crosstalk

Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some NPC patients have bone metastases at the time initial diagnosis. Bone metastasis can cause pathologic fractures pain, reducing patients' quality life, is associated with worse survival. This study aims to unravel complex role insulin-like growth factor 1 receptor (IGF-1R) metastasis, offering insights into potential therapeutic targets. We assessed IGF-1R expression cells explored its correlation metastasis. Experiments investigated impact osteoclast-secreted IGF-1 on IGF-1R/AKT/S6 pathway promoting cell proliferation within marrow. Additionally, reciprocal influence tumor-secreted Granulocyte-macrophage colony-stimulating (GM-CSF) osteoclast differentiation resorption was examined. The effects neutralizing antibody, inhibitor (NVP-AEW541) mTORC (rapamycin) nasopharyngeal were also animal experiments. Elevated correlated an increased tendency for IGF-1, secreted by osteoclasts, activated pathway, Tumor-secreted GM-CSF further stimulated differentiation, exacerbating resorption. NVP-AEW541 rapamycin respectively effective slowing down rate destruction. intricate interplay among IGF-1R, highlights targets precise control providing valuable developing targeted interventions.