Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

• DOI: 10.1186/s13048-018-0400-5
• Publication Date: 2018-04-04T04:25:02Z
• Authors: Sarwat Jahan; Abira Abid; Sidra Khalid; Tayyaba Afsar; Qurat-Ul-Ain; Ghazala Shaheen; Ali Almajwal; Suhail Razak
• Keywords: Letrozole; Lipid Profile

PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects quercetin in letrozole induced rat model polycystic ovarian syndrome, which displayed both clinical metabolic features as women. Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution carboxymethyl (CMC 0.5%); administered with (1 mg/kg) dissolved Metformin given metformin (20 + mg/kg); Quercetin provided (30 mg/kg). All doses orally via gavage, for 21 consecutive days colpocytological analysis was carried till end. After 21rst day, blood taken out, centrifuged plasma kept biochemical (ELISA, anti-oxidant enzymes, lipid profile) reproductive organs dissected out histopathological evaluation. chief member flavonoid, showed beneficial by decreasing body weight, diameter, cysts restoring healthy follicles, follicle's extra-glandular layers, corpora lutea contrast to positive control. Additionally, profile status also maintained baseline very high diseased (p < 0.001).Quercetin depicted mark regulation steroidogenesis levels testosterone (0.78 ng/ml ± 0.14 vs. 1.69 0.17, p 0.001) estradiol (8.85 pg/ml 0.19 1.61 0.29) increasing progesterone (34.47 1.65 11.08 1.17 positive). moderately parallel standard drug available market i.e. metformin. present has confirmed that potentials alleviate hormonal disturbances occurring PCOS.