Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome

Adult Male Delayed Diagnosis Critical Illness 610 Critical Care and Intensive Care Medicine Influenzavirus Statistics, Nonparametric 03 medical and health sciences Influenza A Virus, H1N1 Subtype 0302 clinical medicine Diagnòstic Risk Factors 616 Diagnosis Influenza, Human Odds Ratio Influenza viruses Humans Hospital Mortality Prospective Studies Mortality Critically ill Outcome Aged Chi-Square Distribution Research Length of Stay Middle Aged Influenza A (H1N1)pdm09 virus infection Early diagnosis Late diagnosis 3. Good health Intensive Care Units Logistic Models Spain ICU Female
DOI: 10.1186/s13054-016-1512-1 Publication Date: 2016-10-17T16:02:52Z
ABSTRACT
Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during season. The objective study was assess impact a delay in diagnosis community-acquired infection on clinical outcome critically ill patients admitted ICU.A prospective multicenter observational cohort based data from GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All which had been established within first week hospitalization were included. classified into two groups according time at made: early (within 2 days hospital admission) and late (between 3rd 7th day admission). Factors associated assessed logistic regression analysis.In 2059 diagnosed 7 hospitalization, 1314 (63.8 %) remaining 745 (36.2 %). Independent variables related were: age (odds ratio (OR) = 1.02, 95 % confidence interval (CI) 1.01-1.03, P < 0.001); seasonal period (2009-2012) (OR 2.08, CI 1.64-2.63, stay before 1.26, 1.17-1.35, mechanical ventilation 1.58, 1.17-2.13, 0.002); continuous venovenous hemofiltration 1.54, 1.08-2.18, 0.016). intra-ICU significantly higher among as compared (26.9 vs 17.1 %, 0.001). Diagnostic one independent risk factor for 1.36, 1.03-1.81, 0.001).Late is admission, greater possibilities respiratory renal failure, rate. Delay flu variable death.
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