Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome

• DOI: 10.1186/s13054-016-1512-1
• Publication Date: 2016-10-17T16:02:52Z
• Authors: Francisco Álvarez...; Judith Marín-Corral; Clara Vila; Joan Ramón Masclans; Francisco Javier ...; Ignacio Martín Lo...; Sandra Barbadillo; Alejandro Rodríguez
• Keywords: Adult; Male; Delayed Diagnosis; Critical Illness; 610; Critical Care and Intensive Care Medicine; Influenzavirus; Statistics, Nonparametric; 03 medical and health sciences; Influenza A Virus, H1N1 Subtype; 0302 clinical medicine; Diagnòstic; Risk Factors; 616; Diagnosis; Influenza, Human; Odds Ratio; Influenza viruses; Humans; Hospital Mortality; Prospective Studies; Mortality; Critically ill; Outcome; Aged; Chi-Square Distribution; Research; Length of Stay; Middle Aged; Influenza A (H1N1)pdm09 virus infection; Early diagnosis; Late diagnosis; 3. Good health; Intensive Care Units; Logistic Models; Spain; ICU; Female

Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during season. The objective study was assess impact a delay in diagnosis community-acquired infection on clinical outcome critically ill patients admitted ICU.A prospective multicenter observational cohort based data from GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All which had been established within first week hospitalization were included. classified into two groups according time at made: early (within 2 days hospital admission) and late (between 3rd 7th day admission). Factors associated assessed logistic regression analysis.In 2059 diagnosed 7 hospitalization, 1314 (63.8 %) remaining 745 (36.2 %). Independent variables related were: age (odds ratio (OR) = 1.02, 95 % confidence interval (CI) 1.01-1.03, P < 0.001); seasonal period (2009-2012) (OR 2.08, CI 1.64-2.63, stay before 1.26, 1.17-1.35, mechanical ventilation 1.58, 1.17-2.13, 0.002); continuous venovenous hemofiltration 1.54, 1.08-2.18, 0.016). intra-ICU significantly higher among as compared (26.9 vs 17.1 %, 0.001). Diagnostic one independent risk factor for 1.36, 1.03-1.81, 0.001).Late is admission, greater possibilities respiratory renal failure, rate. Delay flu variable death.