Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis

• DOI: 10.1186/s13054-022-03929-x
• Publication Date: 2022-03-08T10:02:54Z
• Authors: Yueyue Kong; Yi Ye; Jiawei Ma; Guangzhi Shi
• Keywords: Ventriculitis; Procalcitonin; Interquartile range; Cut-off

The sensitive and accurate diagnosis of nosocomial meningitis ventriculitis is still a critical problem. This study was designed to explore the diagnostic value cerebrospinal fluid heparin-binding protein (HBP) in comparison with procalcitonin lactate.In this observational study, 323 suspected patients were enrolled, which 42 participants excluded because they could not be accurately grouped, 131 subjects who eventually diagnosed or 150 whom infection ultimately ruled out included final analysis. main results are expressed as medians (interquartile ranges). Chi-squared test used compare baseline characteristics. Mann-Whitney U-test for group subgroup analyses. area under receiver operating characteristic curve calculated describe accuracy biomarkers. Spearman's partial correlation analyze associations between Statistical significance set when p < 0.05.HBP achieved largest curve, 0.99 (95% confidence interval 0.98-1.00) compared 0.98 0.96-0.99) lactate 0.69 0.62-0.75) procalcitonin. With cutoff level at 23 ng/mL, HBP sensitivity 97%, specificity 95%, positive predictive 93% negative 98%. levels presented no significant discrepancy received previous empiric anti-infective therapy those did (p > 0.05). Higher concentrations present microbiological findings Levels positively correlated polymorphonuclear cell count (Spearman's rho = 0.68, 0.01), white blood 0.57, 0.01) 0.34, 0.01).Cerebrospinal reliable auxiliary marker that preferable over identifying ventriculitis, it also contributes solving difficulties caused by antibiotherapy.