Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study

• DOI: 10.1186/s13054-022-04082-1
• Publication Date: 2022-07-22T10:03:14Z
• Authors: Kamil Polok; Jakub Fronczek; Antonio Artigas; Hans Flaatten; Bertrand Guidet; Dylan W. De Lange; Jesper Fjølner; Susannah Leaver; Michael Beil; Sigal Sviri; Raphael Romano Bruno; Bernhard Wernly; Bernardo Bollen P...; Joerg C. Schefold; Dorota Studzińska; Michael Joannidis; Sandra Oeyen; Brian Marsh; Finn H. Andersen; Rui Moreno; Maurizio Cecconi; Christian Jung; Wojciech Szczeklik; ; Philipp Eller; Michael Joannidis; Dieter Mesotten; Pascal Reper; Sandra Oeyen; Walter Swinnen; Helene Brix; Jens Brushoej; Maja Villefrance; Helene Korvenius ...; Anders Thais Bjer...; Ida Riise Balleby; Kasper Andersen; Maria Aagaard Hansen; Stine Uhrenholt; Helle Bundgaard; Jesper Fjølner; Aliae A. R. Moham...; Rehab Salah; Yasmin Khairy Nas...; Kyrillos Wassim; Yumna A. Elgazzar; Samar Tharwat; Ahmed Y. Azzam; Ayman abdelmawgoa...; Hazem Maarouf Abo...; Mohammed A. Azab; Susannah Leaver; Arnaud Galbois; Bertrand Guidet; Cyril Charron; Emmanuel Guerot; Guillaume Besch; Jean-Philippe Rigaud; Julien Maizel; Michel Djibré; Philippe Burtin; Pierre Garcon; Saad Nseir; Xavier Valette; Nica Alexandru; Nathalie Marin; Marie Vaissiere; Gaëtan Plantefeve; Thierry Vanderlinden; Igor Jurcisin; Buno Megarbane; Anais Caillard; Arnaud Valent; Marc Garnier; Sebastien Besset; Johanna Oziel; Jean-herlé RAPHALEN; Stéphane Dauger; Guillaume Dumas; Bruno Goncalves; Gaël Piton; Eberhard Barth; Ulrich Goebel; Eberhard Barth; Anselm Kunstein; Michael Schuster; Martin Welte; Matthias Lutz; Patrick Meybohm; Stephan Steiner; Tudor Poerner; Hendrik Haake; Stefan Schaller; Stefan Schaller; Stefan Schaller; Detlef Kindgen-Mi...; Christian Meyer; Muhammed Kurt; Karl Friedrich Kuhn; Winfried Randerath; Jakob Wollborn; Zouhir Dindane; Hans-Joachim Kabitz; Ingo Voigt; Gonxhe Shala; Andreas Faltlhauser; Nikoletta Rovina; Zoi Aidoni; Evangelia Chrisan...; Antonios Papadogo...; Mohan Gurjar; Ata Mahmoodpoor; Abdullah khudhur ...; Brian Marsh; Ahmed Elsaka; Sigal Sviri; Vittoria Comellini; Ahmed Rabha; Hazem Ahmed; Silvio A. Namendy...; Abdelilah Ghannam; Martijn Groenendijk; Marieke Zegers; Dylan de Lange; Alex Cornet; Mirjam Evers; Lenneke Haas; Tom Dormans; Willem Dieperink; Luis Romundstad; Britt Sjøbø; Finn H. Andersen; Hans Frank Strietzel; Theresa Olasveengen; Michael Hahn; Miroslaw Czuczwar; Ryszard Gawda; Jakub Klimkiewicz; Maria de Lurdes C...; André Gordinho; Henrique Santos; Rui Assis; Ana Isabel Pinho ...; Mohamed Raafat Ba...; David Perez-Torres; Gemma Gomà; Mercedes Ibarz Vi...; Angela Prado Mira; Patricia Jimeno C...; Susana Arias Rivera; Teresa Tomasa; David Iglesias; Eric Mayor Vázquez; Cesar Aldecoa; Aida Fernández Fe...; Begoña Zalba-Etayo; Isabel Canas-Perez; Luis Tamayo-Lomas; Cristina Diaz-Rod...; Susana Sancho; Jesús Priego; Enas M. Y. Abualq...; Momin Majed Yousu...; Mahmoud Saleh; Nawfel Ben-HAmouda; Andrea Roberti; Alexander Dullenkopf; Yvan Fleury; Bernardo Bollen P...; Joerg C. Schefold; Mohammed Al-Sadawi
• Keywords: SOFA score; Clinical endpoint

Abstract Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical (IMV) with particular importance amidst the shortage of intensive care unit (ICU) beds during COVID-19 pandemic. We aimed evaluate use NIV in Europe and factors associated outcomes patients treated NIV. Methods This substudy COVIP study—an international prospective observational study enrolling aged ≥ 70 years confirmed ICU. enrolled 156 ICUs across 15 European countries between March 2020 April 2021.The primary endpoint was 30-day mortality. Results Cohort included 3074 patients, most whom were male (2197/3074, 71.4%) at mean age 75.7 (SD 4.6). frequency 25.7% varied from 1.1 62.0% participating countries. Primary failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred 470/629 (74.7%) patients. Factors increased failure risk higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) Clinical Frailty Scale (CFS) on admission 1.46, 1.06–2.00). Patients initially (n = 630) lived 1.36 fewer (95% − 2.27 0.46 days) compared IMV group 1876). Conclusions Frequency varies Higher severity illness more severe frailty among critically ill older adults COVID-19. better than Trial Registration NCT04321265 , registered 19 2020, https://clinicaltrials.gov .