Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer

• DOI: 10.1186/s13059-015-0719-9
• Publication Date: 2015-07-20T04:47:46Z
• Authors: Sehrish Rafique; Jeremy S. Thomas; Duncan Sproul; Wendy A. Bickmore
• Keywords: Cell Nucleus; 0301 basic medicine; Transcription, Genetic; Research; Breast Neoplasms; Estrogens; Chromatin; Epigenesis, Genetic; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Receptors, Estrogen; Cell Line, Tumor; MCF-7 Cells; Humans; Female

Epigenetic changes are being increasingly recognized as a prominent feature of cancer. This occurs not only at individual genes, but also over larger chromosomal domains. To investigate this, we set out to identify large domains epigenetic dysregulation in breast cancers.We regions coordinate down-regulation gene expression, and other activation, cancers show that these linked tumor subtype. In particular group coordinately regulated expressed luminal, estrogen-receptor positive tumors cell lines. For one regional regulation is accompanied by visible unfolding large-scale chromatin structure repositioning the region within nucleus. MCF7 cells, this depends on presence estrogen.Our data suggest liganded estrogen receptor long-range higher-order organization may well drugs targeting histone modifications, it will be valuable inhibition protein complexes involved folding cancer cells.