Homeobox oncogene activation by pan-cancer DNA hypermethylation

• DOI: 10.1186/s13059-018-1492-3
• Publication Date: 2018-08-10T09:36:06Z
• Authors: Jianzhong Su; Yung-Hsin Huang; Xiaodong Cui; Xinyu Wang; Xiaotian Zhang; Yong Lei; Jianfeng Xu; Xueqiu Lin; Kaifu Chen; Jie Lv; Margaret A. Goodell; Wei Li
• Keywords: Human genetics; Genome Biology

Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation well studied, what extent epigenetic mechanisms, such as DNA methylation, can induce expression remains unknown.