Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection

• DOI: 10.1186/s13059-020-02007-1
• Publication Date: 2020-04-28T06:02:55Z
• Authors: Qiang Zhang; Jin Hu; Jia-Wu Feng; Xiao-Tong Hu; Ting Wang; Wen-Xiao Gong; Kun Huang; Yi-Xiong Guo; Zhong Zou; Xian Lin; Run Zhou; Yu-Qi Yuan; An-Ding Zhang; Hong Wei; Gang Cao; Chen Liu; Ling-Ling Chen; Mei-Lin Jin
• Keywords: Bifidobacterium animalis

Abstract Background Influenza is a severe respiratory illness that continually threatens global health. It has been widely known gut microbiota modulates the host response to protect against influenza infection, but mechanistic details remain largely unknown. Here, we took advantage of phenomenon lethal dose 50 (LD ) and metagenomic sequencing analysis identify specific anti-influenza microbes analyze underlying mechanism. Results Transferring fecal from mice survive virulent H7N9 infection into antibiotic-treated confers resistance infection. Some exhibit differential features depending on outcome. Bifidobacterium pseudolongum animalis levels are significantly elevated in surviving when compared dead or mock-infected mice. Oral administration B. alone combination both reduces severity germ-free Functional suggests mediates effect via several metabolic molecules. In vivo tests confirm valine coenzyme A produce an effect. Conclusions These findings show closely related heterogeneous responses microbiota. We demonstrate , also find population endogenous can expand enhance occurs, representing novel interaction between Further, our data suggest potential utility prevention as prognostic predictor influenza.