Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial

• DOI: 10.1186/s13063-020-04809-x
• Publication Date: 2021-01-06T20:05:26Z
• Authors: Thiago Augusto Az...; Gudrun Kunst; Caetano Nigro Neto; José de Ribamar C...; Carlos Gustavo Sa...; Gisele Medeiros B...; Jéssica Bassani B...; Mario Hiroyuki Hi...
• Keywords: Inflammatory response

Recent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial.We plan to include one hundred patients undergoing elective coronary artery bypass graft who will be receive either volatile anesthetics or total intravenous anesthesia. The primary endpoint of study is assess by measuring PMN-elastase serum levels. Secondary endpoints levels other pro-inflammatory markers (IL-1β, IL-6, IL-8, TNFα), anti-inflammatory cytokines (TGFβ and IL-10), microRNA expression peripheral blood achieve possible epigenetic mechanisms process. In addition clinical such as presence major complications postoperative period length hospital intensive care unit stay assessed.The trial may determine whether adding anesthetic attenuate response.ClinicalTrials.gov NCT02672345 . Registered on February 2016 updated June 2020.