The telomere maintenance mechanism spectrum and its dynamics in gliomas

• DOI: 10.1186/s13073-022-01095-x
• Publication Date: 2022-08-11T11:07:18Z
• Authors: Sojin Kim; Tamrin Chowdhury; Hyeon Jong Yu; Jee Ye Kahng; Chae Eun Lee; Seung Ah. Choi; Kyung-Min Kim; Ho Kang; Joo Ho Lee; Soon-Tae Lee; Jae-Kyung Won; Kyung Hyun Kim; Min-Sung Kim; Ji Yeoun Lee; Jin Wook Kim; Yong-Hwy Kim; Tae Min Kim; Seung Hong Choi; Ji Hoon Phi; Young-Kyoung Shin; Ja-Lok Ku; Sungyoung Lee; Hongseok Yun; Hwajin Lee; Dokyoung Kim; Kyoungmi Kim; Junho K. Hur; Sung-Hye Park; Seung-Ki Kim; Chul-Kee Park
• Keywords: ATRX; Tumor progression

The activation of the telomere maintenance mechanism (TMM) is one critical drivers cancer cell immortality. In gliomas, TERT expression and promoter mutation are considered to reliably indicate telomerase activation, while ATRX and/or loss indicates an alternative lengthening telomeres (ALT). However, these relationships have not been extensively validated in tumor tissues.