A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys

Spontaneous Cynomolgus monkeys Diseases of the musculoskeletal system Spine Radiographic examination 3. Good health Macaca fascicularis 03 medical and health sciences 0302 clinical medicine RC925-935 Models, Animal Disease Progression Animals Humans Animal model Spondylitis, Ankylosing Hematological testing Ankylosing spondylitis Research Article
DOI: 10.1186/s13075-021-02679-5 Publication Date: 2022-01-03T05:07:04Z
ABSTRACT
Abstract Background Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rodent models which retain only partial clinical features. There is obviously a lack of a useful disease model to conduct comprehensive mechanistic studies. Methods We followed a group of cynomolgus monkeys having joint lesions reported of spinal stiffness for 2 years by conducting hematological testing, radiographic examination, family aggregation analysis, pathological analysis, and genetic testing. Results The results confirmed that these diseased animals suffered from spontaneous ankylosing spondylitis with clinical features recapitulating human ankylosing spondylitis disease progression, manifested by pathological changes and biochemical indicators similar to that of ankylosing spondylitis patients. Conclusion The study offers a promising non-human primate model for spontaneous ankylosing spondylitis which may serve as an excellent substitute for its pre-clinical research.
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