Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study

• DOI: 10.1186/s13104-018-3293-x
• Publication Date: 2018-04-04T04:43:22Z
• Authors: Ramandeep Singh; Pieter F. de Groot; Suzanne E. Geerlings; Caspar J. Hodiamont; Clara Belzer; Ineke J. M. ten B...; Willem M. de Vos; Frederike J. Beme...; Max Nieuwdorp
• Keywords: Fecal bacteriotherapy; Colonisation resistance

Infections with multidrug-resistant microorganisms are associated increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) FMT. Seven underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to total number of 22 transplants. The objective was decolonization ESBL-EB.Three out fifteen (20%) were ESBL-negative at 1, 2 the first transplant, while six (40%) negative transplant. Comparison baseline revealed restoration microbial diversity shift towards donor composition. Finally, suggest several possible factors response therapy, such as donor-recipient match FMTs. Therefore, can be an effective treatment in ESBL-EB. Response may determined by composition procedures. Trial registration ISRCTN ISRCTN48328635 Registered 11 October 2017, retrospectively registered.