N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine, a zinc chelator, inhibits biofilm and hyphal formation in Trichosporon asahii

• DOI: 10.1186/s13104-020-04990-x
• Publication Date: 2020-03-10T09:03:33Z
• Authors: Sanae Kurakado; Ryota Chiba; Chisato Sato; Yasuhiko Matsumoto; Takashi Sugita
• Keywords: Ethylenediaminetetraacetic acid; Ethylene diamine

Abstract Objective Trichosporon asahii is the major causative fungus of disseminated or deep-seated trichosporonosis and forms a biofilm on medical devices. Biofilm formation leads to antifungal drug resistance, so biofilm-related infections are relatively difficult treat infected devices often require surgical removal. Therefore, prevention important in clinical settings. In this study, identify metal cations that affect formation, we evaluated effects cation chelators T. . Results We effect since microorganisms must assimilate essential nutrients from their hosts form maintain biofilms. The inhibition by N , N′,N′ -tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) was greater than those other chelators, such as deferoxamine, triethylenetetramine, ethylenediaminetetraacetic acid. inhibitory TPEN suppressed addition zinc. also inhibited hyphal which related These results suggest zinc for formation. Thus, have potential be developed into new treatment infection caused