Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans

Ancestry Asians/genetics 0301 basic medicine DNA methylation Research 610 DNA Methylation United Kingdom White People 3. Good health 03 medical and health sciences /dk/atira/pure/core/keywords/population_health_SRI Asian People Risk Factors /dk/atira/pure/core/keywords/population_health_SRI; name=Bristol Population Health Science Institute Ethnicity Humans Epigenetics mQTLs name=Bristol Population Health Science Institute Whites/genetics
DOI: 10.1186/s13148-022-01351-2 Publication Date: 2022-10-15T13:02:31Z
ABSTRACT
AbstractEthnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently, there is little knowledge of how DNA methylation varies between South Asian and European ethnicities. This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts: Southall and Brent Revisited and Born in Bradford. DNA methylation differences between ethnicities were widespread throughout the genome (n = 16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity-associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (92)
CITATIONS (28)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....