Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
Ancestry
Asians/genetics
0301 basic medicine
DNA methylation
Research
610
DNA Methylation
United Kingdom
White People
3. Good health
03 medical and health sciences
/dk/atira/pure/core/keywords/population_health_SRI
Asian People
Risk Factors
/dk/atira/pure/core/keywords/population_health_SRI; name=Bristol Population Health Science Institute
Ethnicity
Humans
Epigenetics
mQTLs
name=Bristol Population Health Science Institute
Whites/genetics
DOI:
10.1186/s13148-022-01351-2
Publication Date:
2022-10-15T13:02:31Z
AUTHORS (12)
ABSTRACT
AbstractEthnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently, there is little knowledge of how DNA methylation varies between South Asian and European ethnicities. This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts: Southall and Brent Revisited and Born in Bradford. DNA methylation differences between ethnicities were widespread throughout the genome (n = 16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity-associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research.
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