Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

• DOI: 10.1186/s13223-017-0182-0
• Publication Date: 2017-02-08T12:21:18Z
• Authors: Rachel Caswell-Smith; Terrianne Cripps; Thom Charles; Alexander Hosking; Meghana Handigol; Cecile Holweg; John Matthews; Mark Holliday; Corentin Maillot; James Fingleton; Mark Weatherall; Richard Beasley; Irene Braithwaite
• Keywords: Periostin; Variation (astronomy)

Abstract Background We aimed to determine the effect of sampling time during day on serum periostin levels in adult participants with and without asthma. Methods Serum was measured at 2-h intervals from 0800 1800 h 16 stable asthma prescribed inhaled corticosteroid long-acting beta-agonist therapy, otherwise healthy Mixed linear models were used compare zero (08:00 h) subsequent measurement for both groups. Results In non-asthma, mean (SD) continuously reduced 53.5 (13.6) ng/mL 50.9 (13.4) (difference log −0.05, P ≤ 0.001) 50.5 (13.0) 46.2 (11.5) −0.08, respectively. Conclusions Periostin values are higher morning compared afternoon asthmatic non-asthmatic adults. The small magnitude variation suggests that which measurements made is unlikely influence treatment decisions if a specific level predict responsiveness. Trial registration Australia New Zealand Trials Registry (ACTRN12614000072617)