Differential abscopal effect in extracranial and intracranial lesions after radiotherapy alone for vertebral bone metastasis of unknown primary: a case report

• DOI: 10.1186/s13256-022-03321-x
• Publication Date: 2022-03-06T00:02:21Z
• Authors: Yojiro Ishikawa; Rei Umezawa; Takaya Yamamoto; Noriyoshi Takahashi; Kazuya Takeda; Yu Suzuki; Keiichi Jingu
• Keywords: Abscopal effect

Abstract Background The abscopal effect is a phenomenon in which tumor located far from irradiated lesions regresses. We have experienced case both intracranial and extracranial showed an after radiotherapy for spinal metastases of unknown primary. report the differential lesions. Case presentation A 57-year-old Japanese man was diagnosed with multiple lung nodules, bone metastases, brain metastases. results pathological examination at previous hospital he visited suggested adenocarcinoma lung. However, there possibility that biopsy specimen inadequate. Radiation therapy performed on ninth thoracic vertebra total dose 39 Gy 13 fractions because lesion destructively extending. After thorough examination, primary could not be identified, we made diagnosis cancer patient did want to receive systemic chemotherapy; however, all except had spontaneously shrunk 2 months radiation therapy. Although partially shrunk, whole-brain 36 12 performed. Fifteen initial therapy, metastasis recurred, Gamma Knife radiosurgery additionally disappeared radiosurgery. During period 30 vertebra, trunk maintained their shrinkage without chemotherapy. Right cervical lymph node occurred right led clear cell carcinoma. considered additional or chemotherapy, died 3 progression recurrence Discussion conclusions rare alone metastatic resulted Notably, weaker than