Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway

• DOI: 10.1186/s13287-018-0804-6
• Publication Date: 2018-03-09T08:32:09Z
• Authors: Ruili Yang; Tingting Yu; Dawei Liu; Songtao Shi; Yanheng Zhou
• Keywords: Fas ligand

Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an environmental pollutant, but also important biological gas transmitter health disease. We used in-vitro coculture system a mouse colitis model compare the immunomodulatory effects between control H2S-deficient GMSCs. The flow cytometry analysis was for T-cell apoptosis T-helper 17 (Th17) regulatory T (Treg) cell differentiation. revealed that GMSCs exerted their effect by inducing apoptosis, promoting Treg polarization, inhibiting Th17 polarization vitro. levels of H2S regulated Mechanically, deficiency downregulated expression Fas GMSCs, resulting reduced secretion monocyte chemotactic protein 1 (MCP-1), which turn led decreased migration mediated MCP-1. Moreover, ligand (FasL) Fas/FasL coupling-induced attenuated Consistent with this, showed therapeutic on vivo, could be restored treatment donor, NaHS. These findings required maintain apoptosis.