Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats

• DOI: 10.1186/s13395-018-0164-z
• Publication Date: 2018-05-31T11:56:20Z
• Authors: Dongtao Wang; Lianbo Wei; Yajun Yang; Huan Liu
• Keywords: Muscle Atrophy

A low-protein diet supplemented with ketoacids (LPD + KA) maintains the nutritional status of patients chronic kidney disease (CKD). Oxidative damage and mitochondrial dysfunction associated upregulation p66SHC FoxO3a have been shown to contribute muscle atrophy. This study aimed determine whether LPD KA improves atrophy attenuates oxidative stress observed in CKD rats. 5/6 nephrectomy rats were randomly divided into three groups fed either 22% protein (normal-protein diet; NPD), 6% (low-protein diets; LPD) or 5% plus 1% for 24 weeks. Sham-operated NPD intake used as control. supplementation improved function It also reduced genes related ubiquitin-proteasome system 26S proteasome activity, well muscles Moreover, prevented drastic decrease activities electron transport chain complexes, respiration, content Furthermore, reversed elevation p66Shc expression Our results showed that be beneficial LPD, which might improvement through suppression FoxO3a.