Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study

• DOI: 10.1186/s13550-017-0352-6
• Publication Date: 2018-01-01T20:40:26Z
• Authors: J. E. Mongula; F. C. H. Bakers; S. Vöö; L. Lutgens; T. van Gorp; R. F. P. M. Kruit...; B. F. M. Slangen
• Keywords: Science & Technology; ACCURACY; Radiology, Nuclear Medicine & Medical Imaging; R895-920; Preliminary Research; F-18-FDG PET/CT; CANCER; DISEASE; 3. Good health; CHEMORADIATION THERAPY; Radiation therapy; MALIGNANCIES; Medical physics. Medical radiology. Nuclear medicine; 03 medical and health sciences; PET; 0302 clinical medicine; PET-MRI; SURVIVAL; Cervical cancer; Life Sciences & Biomedicine; MRI

Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control a prerequisite for cure. Imaging after treatment controversial. Positron emission tomography (PET) combined with computer (PET-CT) shows great promise detecting metastases. On the other hand, magnetic resonance imaging (MRI) superior in depicting anatomical details. The combination of PET-MRI could result more accurate evaluation outcome. aim this pilot study to share our initial experience response radiation treatment.Ten patients carcinoma (FIGO ≥IB2) were prospectively evaluated. Eleven weeks (median; range 8-15 weeks) therapy, was evaluated PET-MRI. PET, MRI, and images presence local residual metastasis. Diagnostic performance assessed area under receiver operator characteristic (ROC) curve tumor. readers blinded outcome data. disease, metastasis, diagnostic confidence, change opinion scored on 5-point Likert scale. reference standard consisted pathology and/or follow-up according clinical guidelines.Three out ten had abnormalities suggestive residue treatment. availability both PET MRI resulted an increase confidence 80-90% all patients. Change observed 70% policy 50%, especially group accuracy increased significantly radiologist if (AUC .54 versus .83).PET-MRI cancer, increasing while potentially performance.