[68 Ga]Ga-FAPI-04 PET/CT may be a predictor for early treatment response in rheumatoid arthritis

• DOI: 10.1186/s13550-023-01064-4
• Publication Date: 2024-01-04T16:01:38Z
• Authors: Qingqing Pan; Huaxia Yang; Ziyue Zhou; Min Li; Xu Jiang; Fang Li; Yaping Luo; Mengtao Li
• Keywords: Medical physics. Medical radiology. Nuclear medicine; 03 medical and health sciences; 0302 clinical medicine; PET/CT; R895-920; [68 Ga]Ga-FAPI-04; Rheumatoid arthritis; [18F]FDG; Treatment response; Original Research

Abstract Background The identification of biomarkers predicting the treatment response rheumatoid arthritis (RA) is important. [ 68 Ga]Ga-FAPI-04 showed markedly increased uptake in joints patients with RA. purpose this study to investigate whether PET/CT can be a predictor Results Nineteen diagnosed RA prospective cohort were finally enrolled. Both total synovitis (TSU) and metabolic volume (MSV) 18 F]FDG responders significantly higher than those non-responders according Clinical Disease Activity Index (CDAI) Simplified (SDAI) criteria at 3-months’ follow-up ( P < 0.05). PET joint count (PJC) detected also CDAI = 0.016 0.045, respectively). clinical characteristics disease activity baseline did not show significant difference between non-responders, except CRP 0.035 0.033 SDAI criteria, PJC FAPI , TSU MSV > cutoff values successfully discriminated follow-up. Conclusion early non-responders. Trial registration ClinicalTrials. NCT04514614. Registered 13 August 2020, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000A4PN&selectaction=Edit&uid=U0001JRW&ts=2&cx=-x9t7cp