Post-entry blockade of small ruminant lentiviruses by wild ruminants

• DOI: 10.1186/s13567-015-0288-7
• Publication Date: 2016-01-06T04:32:41Z
• Authors: Leticia Sanjosé; Helena Crespo; Laure Blatti-Card...; Idoia Glaria; Carlos Martínez-C...; Eduardo Berriatua; Beatriz Amorena; Damián De Andrés; Giuseppe Bertoni; Ramses Reina
• Keywords: [SDV]Life Sciences [q-bio]; Sheep Diseases; Animals, Wild; Enzyme-Linked Immunosorbent Assay; Antibodies, Viral; Virus Replication; Small ruminants lentiviruses (SRLV); 03 medical and health sciences; Antibody Specificity; Animals; Wild ruminants; Fallow Deer; Sheep, Domestic; 2. Zero hunger; 0303 health sciences; Sheep; 630 Agriculture; Deer; Lentivirus; Fibroblasts; Virus Internalization; veterinary(all); 3. Good health; [SDV] Life Sciences [q-bio]; Wild Ruminant; Lentivirus Infections; 570 Life sciences; biology; Simian Immunodeficiency Virus; Bovine Immunodeficiency Virus; Infection; Peptide 126M1; Research Article

Small ruminant lentivirus (SRLV) infection causes losses in the small industry due to reduced animal production and increased replacement rates. Infection of wild ruminants close contact with infected domestic animals has been proposed play a role SRLV epidemiology, but studies are limited mostly involve hybrids between animals. In this study, seropositive red deer, roe deer mouflon were detected through modified ELISA tests, virus was not successfully amplified using set different PCRs. Apparent restriction cervids related presence neutralizing antibodies. vitro cultured skin fibroblastic cells from fallow permissive entry integration, produced low quantities virus. got rapidly adapted blood-derived macrophages deer. Thus, although direct detection achieved vivo, these findings show potential susceptibility case and, on other hand, an vivo Altogether results may highlight importance surveilling controlling as well sharing pasture areas, provide new natural tools control spread sheep goats.