Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

• DOI: 10.1186/s13613-022-01071-z
• Publication Date: 2022-10-17T14:09:13Z
• Authors: Ines Ziriat; Aurélie Le Thuaut; Gwenhael Colin; Hamid Merdji; Guillaume Grillet; Patrick Girardie; Bertrand Souweine; Pierre-François D...; Thierry Boulain; Jean-Pierre Frat; Pierre Asfar; Bruno Francois; Mickael Landais; Gaëtan Plantefeve; Jean-Pierre Quenot; Jean-Charles Chak...; Michel Sirodot; Stéphane Legriel; Nicolas Massart; Didier Thevenin; Arnaud Desachy; Arnaud Delahaye; Vlad Botoc; Sylvie Vimeux; Frederic Martino; Jean Reignier; Alain Cariou; Jean Baptiste Las...
• Keywords: Post-hoc analysis; Targeted temperature management

Abstract Background Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. We performed a HYPERION trial data to assess potential associations linking non-shockable °C on favourable functional outcome. Methods divided patients into groups vs. without (defined as need for vasoactive drugs) then assessed proportion outcome (day-90 Cerebral Performance Category [CPC] 1 or 2) (33 °C) controlled normothermia (37 in each group. Patients norepinephrine epinephrine > µg/kg/min were not included. Results Of 581 included 25 ICUs France and who did withdraw consent, 339 had 242 not. In postresuscitation-shock group, 159 received hypothermia, including 14 day-90 CPC 1–2, 180 normothermia, 10 1–2 (8.81% 5.56%, respectively; P = 0.24). After adjustment, also differ significantly between (adjusted hazards ratio, 1.99; 95% confidence interval, 0.72–5.50; 0.18). Day-90 was comparable these two (83% 86%, 0.43). Conclusions arrest, mild-to-moderate intensive-care-unit admission seem associated survival. Therapeutic worse outcomes compared shock. Trial registration ClinicalTrials.gov, NCT01994772