Association between frailty, delirium, and mortality in older critically ill patients: a binational registry study

• DOI: 10.1186/s13613-022-01080-y
• Publication Date: 2022-11-17T12:03:54Z
• Authors: Berhe W. Sahle; David Pilcher; Edward Litton; Richard Ofori-Asenso; Karlheinz Peter; James McFadyen; Tracey Bucknall
• Keywords: Odds

Frailty and delirium are prevalent among older adults admitted to the intensive care unit (ICU) associated with adverse outcomes; however, their relationships have not been extensively explored. This study examined association between frailty mortality length of hospital stay (LOS) in ICU patients, whether associations mediated or modified by an episode delirium.Retrospective analysis data from Australian New Zealand Intensive Care Society Adult Patient Database. A total 149,320 patients aged 65 years 203 participating ICUs 1 January 2017 31 December 2020 who had for were included analysis.A 41,719 (27.9%) frail on admission, 9,179 (6.1%) developed during admission. Frail significantly higher odds in-hospital (OR: 2.15, 95% CI 2.05-2.25), episodes 1.86, 1.77-1.95), longer LOS (log-transformed mean difference (MD): 0.24, 0.23-0.25). Acute was 32% increased 1.32, 1.23-1.43) (MD: 0.54, 0.50-0.54). The ratios (95% CI) 1.37 (1.23-1.52), 2.14 (2.04-2.24) 2.77 (2.51-3.05) non-frail delirium, without respectively. There very small but statistically significant effect (b indirect effect: 0.00037, P < 0.001) 0.019, through delirium.Both independently increase risk LOS. is more common patients; it does mediate modify a clinically meaningful amount