Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis

• DOI: 10.1186/s13643-018-0774-x
• Publication Date: 2018-07-25T14:13:32Z
• Authors: Mohammed Akibu; Tesfalidet Tekelab; Abdella Amano; Merga Besho; Stephanie Grutzma...; Mesfin Tadese; Tesfa Dejenie Hab...
• Keywords: Folic acid supplementation

Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, perinatal maternal morbidity mortality. However, its has not been successful that attributed to several determinants including poor adherence. Therefore, we aimed conduct a systematic review meta-analysis on the prevalence of adherence prenatal in low- middle-income countries. In addition, will develop conceptual framework context countries (LMIC). We search PubMed, MEDLINE, EMBASE, EBSCO, Web Science, SCOPUS, WHO Global Index Medicus, African Journals Online (AJOL) databases retrieve relevant literatures. Observational (i.e., case-control, cohort, cross-sectional, survey, surveillance reports) quasi-randomized randomized controlled trial studies conducted LMIC be included. The Newcastle-Ottawa Scale (NOS) Joanna Briggs Institute (JBI) critical appraisal checklist used assess quality observational respectively. pooled odds ratio generated using weighted inverse-variance model. Statistical heterogeneity among assessed by Cochran's Q χ2 statistics Higgins (I2 statistics) method. result presented forest plots Harvest when necessary. Furthermore, perform Jackknife sensitivity subgroup analysis. Data analyzed comprehensive software (version 2). Contemporary evidence about synthesized generate up-to-date knowledge. To our knowledge, this is first review. It would have substantial implications for researchers, clinicians, policymakers optimizing child health LMIC. protocol registered International Prospective Register Systematic Review (PROSPERO), University York Center Reviews Dissemination ( https://www.crd.york.ac.uk/ ), registration number CRD42017080245 .