The emergence of carbapenem resistant Klebsiella pneumoniae in Malaysia: correlation between microbiological trends with host characteristics and clinical factors

• DOI: 10.1186/s13756-016-0164-x
• Publication Date: 2017-01-07T00:49:41Z
• Authors: Ye-Mun Low; Polly Soo-Xi Yap; Kartini Abdul Jabar; Sasheela Ponnampa...; Rina Karunakaran; Rukumani Velayuthan; Chun-Wie Chong; Sazaly Abu Bakar; Mohd Yasim Md Yusof; Cindy Shuan-Ju Teh
• Keywords: Medical microbiology; Carbapenem; Multi drug resistant; Klebsiella; Host factors

Carbapenem resistant Enterobacteriaceae is a growing concern worldwide including Malaysia. The emergence of this pathogen worrying because carbapenem one the 'last-line' antibiotics. main objective study was to determine prevalence genetic mechanisms and clinical risk factors Klebsiella pneumoniae (K. pneumoniae) in In study, seventeen K. strains isolated from tertiary teaching hospital 2013 were studied. Minimal inhibitory concentration (MIC) bacterial determined genes associated with carbapenemases extended-spectrum-beta-lactamases (ESBLs) sequenced compared closest representatives published public domains. All also sub-typed using pulsed-field gel electrophoresis (PFGE) multilocus sequence typing (MLST). Statistical analyses performed correlation between for acquiring in-hospital mortality. predominant carbapenemase bla OXA-48, detected 12 (70.59%). Other KPC-2, IMP-8, NMC-A NDM-1. Nine different pulsotypes identified nine which affiliated ST101, type had similar PFGE patterns (similarity index 85%). Based on univariate statistical analysis, resistance imipenem usage mechanical ventilation showed statistically significant effect separately diverse harbored by these facilitates its spread complicates detection. Thus, microbiological trends host characteristics will provide better insight rational treatment strategies control.