The association of serum albumin with 28 day mortality in critically ill patients undergoing dialysis: a secondary analysis based on the eICU collaborative research database

• DOI: 10.1186/s40001-024-02127-5
• Publication Date: 2024-11-05T03:01:59Z
• Authors: Lanlang Zhang; Ting Deng; Guilin Zeng; Xinglin Chen; Die Wu
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Serum albumin (ALB); Research; 28 day mortality; R; Medicine; Dialysis; Critically Ill patients

The relationship between serum albumin and prognosis in critically ill patients has been studied, however, there is a paucity of exploration into non-linear relationships, particularly undergoing dialysis. This study intends to investigate the association (ALB) 28 day mortality We conducted multi-center retrospective cohort dialysis by utilising data from eICU Collaborative Research Database 208 distinct ICUs across United States 2014 2015. focused on within days ICU admission. employed univariate analysis, multi-factor logistic regression, subgroup curve-fitting, threshold effect analysis examine correlation ALB levels mortality. Among 2,315 with median age 63 years, 205 (8.86%) died When level was < 2.7 g/dL, decreased an adjusted odds ratio (OR) 0.34 (95% CI 0.22–0.51, P 0.0001) for every 1 increment ALB. However, no significant changes were observed when at or above this threshold. Our identifies nonlinear dose–response dialysis, specific turning point observed. finding underscores negative risk, lower being associated higher risk particular population.