Dihydroartemisinin inhibits lung cancer bone metastasis by modulating macrophage polarization

• DOI: 10.1186/s40001-025-02467-w
• Publication Date: 2025-04-05T06:28:26Z
• Authors: Guihua Hang; Xia Gu; Yuanyuan Gu; Ping Gan; Chunwang Hua; Aiming Chen
• Keywords: Dihydroartemisinin; Macrophage polarization

The high metastasis rate of lung cancer contributes to its low 5-year survival rate. Bone is a common complication in advanced cancer, adversely affecting postoperative recovery. This study investigates the effects DHA on macrophage polarization and underlying mechanisms. In vitro, was found inhibit M2 while promoting M1 macrophages, thereby reducing invasion migration cells. vivo, inhibited growth bone by modulating M1/M2 both tissues metastatic sites. addition, through CCL2/CCR2 pathway, decreased recruitment accumulation. These results suggest that effective inhibiting metastasis, offering promising research application prospects.