Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis

• DOI: 10.1186/s40035-015-0037-x
• Publication Date: 2015-07-28T15:04:13Z
• Authors: Zhen Jiang; Wenzhang Wang; George Perry; Xiongwei Zhu; Xinglong Wang
• Keywords: Mitochondrial disease

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of neurons in brainstem and spinal cord. Currently, there no cure or effective treatment for ALS cause unknown majority cases. Neuronal mitochondria dysfunction one earliest features ALS. Mitochondria are highly dynamic organelles that undergo continuous fission, fusion, trafficking turnover, all which contribute to maintenance mitochondrial function. Abnormal dynamics have been repeatedly reported increasing evidence suggests altered as possible pathomechanisms underlying Here, we provide an overview abnormalities observed ALS, discuss possibility targeting a novel therapeutic approach