Incidence and impact of interstitial lung disease and malignancy in patients with polymyositis, dermatomyositis, and clinically amyopathic dermatomyositis: a retrospective cohort study

• DOI: 10.1186/s40064-015-1013-8
• Publication Date: 2015-05-27T06:52:29Z
• Authors: Satoshi Ikeda; Machiko Arita; Kenta Misaki; Shohei Mishima; Takuya Takaiwa; Akihiro Nishiyama; Akihiro Ito; Kenjiro Furuta; Toshihide Yokoyama; Fumiaki Tokioka; Maki Noyama; Hiroshige Yoshioka; Tadashi Ishida
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Research; 3. Good health

The aims of this study were to retrospectively review Japanese consecutive cases polymyositis (PM), dermatomyositis (DM), and clinically amyopathic (CADM), focusing on interstital lung disease (ILD) malignancy, document any differences in the incidence, clinical features, impact prognosis among patients with PM, DM, CADM. We reviewed 62 diagnosed CADM according Bohan Peter's criteria (PM/DM) Sontheimer's Gerami's ILD malignancy. occurrence rates 48 % (11/23) 46 (11/24) 100 (15/15) Malignancy occurred during diagnosis or observation period 14 patients; 86 without ILD, 64 DM ILD. Multivariate logistic regression analysis showed that risk newly malignancy was significantly lower [odds ratio, 0.0688; 95 confidence interval (CI), 0.00127-0.372; p = 0.00190] higher (odds 5.21; CI, 1.17-23.1; 0.0299) than other patients. Patients malignancies had shorter survival those malignancies; no meaningful difference observed different myositis types for presence In CADM-ILD, 80 fatal died from refractory ≤90 days first visit; neither death nor recurrence subsequently. conclusion, a positive association between negative noted. present study, predictor poor long-term prognosis, but not. associated contributed greatly short-term