Fructose-induced FGF21 secretion does not activate brown adipose tissue in Japanese young men: randomized cross-over and randomized controlled trials

• DOI: 10.1186/s40101-023-00353-0
• Publication Date: 2024-01-04T08:02:31Z
• Authors: Haruki Kataoka; Shinsuke Nirengi; Yuka Matsui; Hirokazu Taniguchi
• Keywords: FGF21

Human brown adipose tissue (BAT) activity is associated with lower body fatness and favorable glucose metabolism. Previous studies reported that oral fructose loading induces postprandial fibroblast growth factor 21 (FGF21) secretion. FGF21 a known inducer of thermogenesis; however, the effects diet-induced secretion on BAT thermogenesis remain to be elucidated. The both single load daily consumption were examined using randomized cross-over trial 2-week controlled (RCT), respectively. In trial, 15 young men consumed dose solution or water then other subsequent day. RCT enrolled 22 men, participants allocated group for 2 weeks. was analyzed thermography cold exposure. Plasma level determined by enzyme-linked immunosorbent assay. single-load plasma levels significantly increased at h after (p < 0.01); there no significant difference in between drinking water. revealed not compared Correlation analyses baseline final measurements strongly positively (r = 0.869, p 0.001). Changes negatively correlated changes during intervention − 0.497, 0.022). Oral temporary increase circulating levels; this does activate healthy men. Further are needed elucidate effect endogenous physiological function. This study registered University Hospital Medical Information Network Japan (number 000051761, 1 August 2023, retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000052680 ).