Variable responses of human and non-human primate gut microbiomes to a Western diet

• DOI: 10.1186/s40168-015-0120-7
• Publication Date: 2015-10-15T02:03:01Z
• Authors: Katherine R. Amato; Carl J. Yeoman; Gabriela Cerda; Christopher A. Sc...; Jennifer Danzy Cr...; Margret E. Berg M...; Andres Gomez; Trudy R. Turner; Brenda A. Wilson; Rebecca M. Stumpf; Karen E. Nelson; Bryan A. White; Rob Knight; Steven R. Leigh
• Keywords: Prevotella; Vervet monkey; Human physiology

The human gut microbiota interacts closely with diet and physiology. To better understand the mechanisms behind this relationship, microbiome research relies on complementing studies manipulations of animal models, including non-human primates. However, due to unique aspects physiology, it is likely that host-gut microbe interactions operate differently in humans Here, we show reacts a high-protein, high-fat Western than model primate, African green monkey, or vervet (Chlorocebus aethiops sabaeus). Specifically, exhibit increased relative abundance Firmicutes reduced Prevotella while vervets opposite pattern. Predictive metagenomics demonstrate an genes associated carbohydrate metabolism only consuming diet. These results suggest has properties are result changes physiology across evolution may have contributed Therefore, role models for understanding relationship between host must be re-focused.