Skin microbiome modulation induced by probiotic solutions

• DOI: 10.1186/s40168-019-0709-3
• Publication Date: 2019-06-24T22:25:41Z
• Authors: Bernhard Paetzold; Jesse R. Willis; João Pereira de Lima; Nastassia Knödlseder; Holger Brüggemann; Sven R. Quist; Toni Gabaldón; Marc Güell
• Keywords: Adult; Male; 0303 health sciences; Bacteria; Microbiota; Probiotics; QR100-130; Short Report; Propionibacteriaceae; Skin Diseases; Bacterial Load; Healthy Volunteers; 3. Good health; Microbial ecology; Young Adult; 03 medical and health sciences; Skin microbiome; Microbiome transplantation; Humans; Female; Cutibacterium acnes; Skin

The skin is colonized by a large number of microorganisms, most which are beneficial or harmless. However, disease states have specific microbiome compositions that different from those healthy skin. Gut modulation through fecal transplant has been proven as valid therapeutic strategy in diseases such Clostridium difficile infections. Therefore, techniques to modulate the composition may become an interesting option affecting psoriasis acne vulgaris.Here, we used mixtures components alter recipient microbiomes.We show after sequential applications donor microbiome, becomes more similar donor. After intervention, initial week-long phase characterized dominance strains. level engraftment depends on and microbiomes, applied bacterial load. We observed higher using multi-strain solution with rich Cutibacterium acnes subtype H1 Leifsonia.We demonstrated use living bacteria composition.