Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA): methods and design of a randomized laboratory study
Motivation
AUD
Alcohol Drinking
Ethanol
Ad-libitum taste-test
BF1-990
3. Good health
TSST
Study Protocol
Alcoholism
03 medical and health sciences
0302 clinical medicine
Impulsive Behavior
Psychology
Humans
Acute stress
Risky alcohol consumption
DOI:
10.1186/s40359-022-00942-1
Publication Date:
2022-10-15T10:02:44Z
AUTHORS (5)
ABSTRACT
Abstract
Background
Excessive alcohol consumption and alcohol use disorders (AUD) are among the leading preventable causes of premature morbidity and mortality and are considered a major public health concern. In order to reduce the individual and societal burden of excessive alcohol use, it is crucial to identify high-risk individuals at earlier stages and to provide effective interventions to prevent further progression. Stressful experiences are important risk factors for excessive alcohol consumption and AUDs. However, the underlying biological and psychological mechanisms are still poorly understood.
Methods
The project “Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA)” is a randomized controlled study that started in December 2018 and is conducted in a laboratory setting, which aims to identify moderators and mediators of the relationship between acute stress and alcohol consumption among regular and risky drinkers. Regular and risky drinkers are randomly assigned to a stress induction or a control condition. Several processes that may mediate (emotional distress, endocrine and autonomic stress reactivity, impulsivity, inhibitory control, motivational sensitization) or moderate (trait impulsivity, childhood maltreatment, basal HPA-axis activity) the relation between stress and alcohol consumption are investigated. As primary dependent variable, the motivation to consume alcohol following psychosocial stress is measured.
Discussion
The results of this study could help to provide valuable targets for future research on tailored interventions to prevent stress-related alcohol consumption.
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