DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

• DOI: 10.1186/s40409-015-0006-y
• Publication Date: 2015-03-24T09:15:46Z
• Authors: Adriana Sierra As...; Larissa Ragozo Ca...; Francilene Capel ...; Carlos Roberto Go...; Suzana Madeira Di...; Sueli Aparecida C...; Fátima Regina Vil...; Paulo Câmara Marq...
• Keywords: Comet Assay

Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It caused by the fungus Lacazia loboi. Herein we report study that relates genotoxicity L. loboi in isogenic mice nutritional status, through normal or restricted diet.DNA damage was assessed peripheral blood comet assay (tail intensity).The results for leukocytes showed increases mean tail intensity under dietary restriction, infected restriction and ingesting diet.These indicate infection may increase DNA levels mice, detected assay.