Carcinoembryonic antigen levels correlated with advanced disease in medullary thyroid cancer

• DOI: 10.1186/s40463-018-0303-x
• Publication Date: 2018-09-17T12:20:27Z
• Authors: Sena Turkdogan; Véronique-Isabell...; Michael P. Hier; Michael Tamilia; Anca Florea; Richard J. Payne
• Keywords: Carcinoembryonic antigen; Medullary Thyroid Cancer; Univariate analysis

Medullary thyroid cancer (MTC) cells are capable of secreting various tumor markers including calcitonin and carcinoembyronic antigen (CEA). The purpose this study is to determine whether abnormal CEA levels may be used as a marker predict the severity disease in MTC.A retrospective analysis was completed for 33 patients with MTC who had preoperative serum levels. Univariate multivariate analyses were quantify relationship between stage prognosis.On analysis, elevated significantly associated size tumor, distant metastasis, decreased biochemical cure, mortality. There significant association greater than 37 mm (> 271 ng/ml). also positive correlation increased 377 ng/ml), metastasis 405 contralateral compartment location lymph node 162 When pre-operative > 500 ng/ml, patient mortality 67%.In study, both correlated extent MTC. While has linear progression, better indicator advanced disease. ng/ml staging, central compartment, chance cure.