Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

• DOI: 10.1186/s40478-022-01448-y
• Publication Date: 2022-10-05T05:02:38Z
• Authors: Qinyuan Alis Xu; Pierre Boerkoel; Veronica Hirsch-R...; Ian R. Mackenzie; Ging-Yuek Robin H...; Geoffrey Charm; Elliott F. To; Alice Q. Liu; Katerina Schwab; Kailun Jiang; Marinko Sarunic; Mirza Faisal Beg; Wellington Pham; Jing Cui; Eleanor To; Sieun Lee; Joanne A. Matsubara
• Keywords: Degeneration (medical); Neuronal Degeneration

Abstract Amyloid beta (Aβ) deposits in the retina of Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on relationship Aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles homeostasis clearance AD retina. Significantly higher load was found compared controls, specifically mid-peripheral region. showed significantly less immunoreactivity against fibrillary acidic protein (GFAP) glutamine synthetase (GS) control eyes. Immunoreactivity ionized calcium binding adapter molecule-1 (IBA-1), microglial marker, demonstrated level microgliosis Within retina, more IBA-1 present which contained than central GFAP co-localized rarely Aβ, while layers donor These results suggest that dysfunction Müller be key features