Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study

Lewy Body Disease 0301 basic medicine Alpha-Synuclein 610 Lewy body disease Neurology and psychiatry 03 medical and health sciences Ganglia, Spinal 80 and over Animals Humans RC346-429 Neuropathology Aged Adrenal gland Aged, 80 and over Spinal cord Research Neurosciences Brain 540 Amygdala 3111 3. Good health Spinal Cord Dorsal root ganglion 3111 Biomedicine Neurology. Diseases of the nervous system
DOI: 10.1186/s40478-022-01487-5 Publication Date: 2022-12-12T05:08:56Z
ABSTRACT
Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation spinal cord and peripheral LRP can elucidate mechanisms Lewy body disorders origins synuclein accumulation. Still, very few unselected studies have focused on in these regions. Here we analysed cord, dorsal root ganglion, adrenal gland population-based Vantaa 85 + study, including every ≥ years old citizen living city 1991 (n = 601). Samples from (C6-7, TH3-4, L3-4, S1-2) were available 303, lumbar ganglion 219, 164 subjects. Semiquantitative scores determined immunohistochemically stained sections (anti-alpha-synuclein antibody 5G4). ventral horns thoracic intermediolateral column, compared with brain LRP, previously according to DLB Consortium criteria by caudo-rostral versus amygdala-based classification. Spinal was found 28% total population 61% those who had brain. only subjects brain, quantity associated severity (p < 0.001). Unsupervised K-means analysis identified cluster types corresponding The type exhibited more frequent severe than type. Analysis specific regions showed that column sacral horn most frequently affected both This study provides support concept at least
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