Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study

• DOI: 10.1186/s40478-022-01487-5
• Publication Date: 2022-12-12T05:08:56Z
• Authors: Anna Raunio; Ville Kivistö; Mia Kero; Jarno Tuimala; Sara Savola; Minna Oinas; Eloise Kok; Kia Colangelo; Anders Paetau; Tuomo Polvikoski; Pentti J. Tienari; Henri Puttonen; Liisa Myllykangas
• Keywords: Lewy Body Disease; 0301 basic medicine; Alpha-Synuclein; 610; Lewy body disease; Neurology and psychiatry; 03 medical and health sciences; Ganglia, Spinal; 80 and over; Animals; Humans; RC346-429; Neuropathology; Aged; Adrenal gland; Aged, 80 and over; Spinal cord; Research; Neurosciences; Brain; 540; Amygdala; 3111; 3. Good health; Spinal Cord; Dorsal root ganglion; 3111 Biomedicine; Neurology. Diseases of the nervous system

Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation spinal cord and peripheral LRP can elucidate mechanisms Lewy body disorders origins synuclein accumulation. Still, very few unselected studies have focused on in these regions. Here we analysed cord, dorsal root ganglion, adrenal gland population-based Vantaa 85 + study, including every ≥ years old citizen living city 1991 (n = 601). Samples from (C6-7, TH3-4, L3-4, S1-2) were available 303, lumbar ganglion 219, 164 subjects. Semiquantitative scores determined immunohistochemically stained sections (anti-alpha-synuclein antibody 5G4). ventral horns thoracic intermediolateral column, compared with brain LRP, previously according to DLB Consortium criteria by caudo-rostral versus amygdala-based classification. Spinal was found 28% total population 61% those who had brain. only subjects brain, quantity associated severity (p < 0.001). Unsupervised K-means analysis identified cluster types corresponding The type exhibited more frequent severe than type. Analysis specific regions showed that column sacral horn most frequently affected both This study provides support concept at least