Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings

• DOI: 10.1186/s40644-018-0144-x
• Publication Date: 2018-04-19T11:31:14Z
• Authors: Ya-ling Chen; Yi Gao; Cai Chang; Fen Wang; Wei Zeng; Jia-jian Chen
• Keywords: Histopathology

Ultrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements change transducer orientation, defined as anisotropy. In this study, we aimed to observe the anisotropy SWE lesions, and its correlation clinical histopathological findings.This retrospective study was approved by institutional review board. From June 2014 2015, a total 276 women (mean age, 48.75 ± 12.12 years) lesions (174 malignant, 102 benign) were enrolled for conventional ultrasound before surgical excision. Elasticity modulus in longest diameter orthogonal recorded, including maximum (Emax), mean (Emean), standard deviation (Esd) ratio between normal fatty tissue (Eratio). Anisotropy coefficients anisotropic difference (AD) factors (AF) calculated, correlations malignancy, tumor size, palpability, movability, location histopathology analyzed.The average Emax, Emean, Esd Eratio significantly higher than (P < 0.05). AUCs ADs AFs inferior quantitative parameters 0.001), superior 0.001). showed no significant distance from nipple skin, patterns. ADmean inner half outer = 0.034). Higher correlated larger size 0.042), palpability 0.05), shorter skin 0.05) suspicion malignancy IDC DCIS Grade II/III I ER/PR(+) 0.05).AF an indicator more aggressive cancer.