Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction

• DOI: 10.1186/s40658-016-0147-2
• Publication Date: 2016-06-29T08:27:34Z
• Authors: Wataru Takeuchi; Atsuro Suzuki; Tohru Shiga; Naoki Kubo; Yuichi Morimoto; Yuichiro Ueno; Keiji Kobashi; Kikuo Umegaki; Nagara Tamaki
• Keywords: Gamma camera

A brain single-photon emission computed tomography (SPECT) system using cadmium telluride (CdTe) solid-state detectors was previously developed. This CdTe-SPECT is suitable for simultaneous dual-radionuclide imaging due to its fine energy resolution (6.6 %). However, the problems of down-scatter and low-energy tail spectral characteristics a pixelated detector should be addressed. The objective this work develop Tc-99m I-123 studies evaluate accuracy.A scatter correction method five windows (FiveEWs) are Tc-lower, Tc-main, shared sub-window Tc-upper I-lower, I-main, I-upper. FiveEW uses pre-measured responses primary gamma rays from each radionuclide compensate overestimation by triple-energy window that used. Two phantom experiments healthy volunteer experiment were conducted system. cylindrical six-compartment with different mixtures cold one scanned. quantitative accuracy evaluated 18 regions interest phantom. In study, volunteers injected human serum albumin diethylene triamine pentaacetic acid (HSA-D) scanned (single acquisition). They then N-isopropyl-4-iodoamphetamine hydrochloride (IMP) again (dual counts images single dual acquisitions compared.In experiments, percentage difference (PD) between 5.7 ± 4.0 % (mean standard deviation). experiment, PDs measured activity 14.4 11.0 2.3 1.8 %, respectively. PD 4.5 3.4 %.This can provide accurate imaging. SPECT will permit study become clinically applicable.