Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice

• DOI: 10.1186/s40659-018-0166-7
• Publication Date: 2018-07-06T01:39:12Z
• Authors: Ruhui Lin; Long Li; Yingzheng Zhang; Sheng Huang; Shangjie Chen; Jiao Shi; Peiyuan Zhuo; Hao Jin; Zuanfang Li; Weilin Liu; Zhifu Wang; Lidian Chen; Jing Tao
• Keywords: Nissl body; Cognitive Decline

To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning memory APP/PS1 mouse was evaluated Morris water maze test step-down avoidance test, neuron survival number neuronal structure hippocampus observed Nissl staining, BDNF phosphorylated TrkB detected Western blot.EA at DU20 acupuncture significantly improve behavioral tests, up-regulate NAA, Glu mI metabolism, increase surviving neurons hippocampus, promote expression transgenic mice.These findings suggested that EA is a potential therapeutic for ameliorate dysfunction, it might be due could NAA upregulation mice.