Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters

• DOI: 10.1186/s40659-024-00508-y
• Publication Date: 2024-05-06T09:01:54Z
• Authors: Binan Zhao; Haoran Peng; Yanjing Zhang; Jie Zhang; Desheng Kong; Sai Cao; Yan Li; Dan Yang; Chuanwen Sun; Xinyi Pu; Ping Zhao; Yan Xu; Kai Zhao; Liangzhi Xie
• Keywords: Pandemic; Yolk

Abstract Despite the record speed of developing vaccines and therapeutics against SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination application remain low countries. Rapid cost mass production antiviral IgY antibodies could an attractive alternative or complementary option for vaccine therapeutic development. this article, we rapidly produced antigens, immunized hens purified 2 months after gene sequence became public. We further demonstrated competitively block RBD binding to ACE2, neutralize authentic virus effectively protect hamsters from challenge by preventing weight loss lung pathology, representing first comprehensive study with antibodies. The process easily implemented most countries hence become new vital our toolbox combating viral This stimulate studies, optimization potential applications as prophylactics human animals.