Resected thymic large cell neuroendocrine carcinoma: report of a case

• DOI: 10.1186/s40792-018-0540-2
• Publication Date: 2018-11-16T07:22:04Z
• Authors: Hiromitsu Domen; Yasuhiro Hida; Masaaki Sato; Haruka Takahashi; Tatsuru Ishikawa; Yosuke Shionoya; Midori Hashimoto; Kaoru Nishiyama; Yuma Aoki; Kazuho Inoko; Syotaro Furukawa; Kazuomi Ichinokawa; Hidehisa Yamada
• Keywords: Thymic carcinoma; Thymectomy; Median sternotomy; Cardiothoracic surgery

Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown. A 90-year-old man with a history diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed anterior mediastinal tumor, measuring 31 mm × 28 in diameter. Magnetic resonance imaging iso-intensity mass on T1-weighted images high intensity T2-weighted images. 18F-Fluorodeoxyglucose-positron emission marked uptake the mass, was diagnosed as invasive thymoma or carcinoma. Video-assisted thoracic surgery through left cavity converted to median sternotomy due severe adhesions between lung chest wall. Partial thymectomy combined partial resection upper lobectomy first second costal cartilages were performed. pathologic diagnosis LCNEC, Masaoka stage III. patient developed pleural dissemination metastases 5 months died 12 after surgery. LCNEC has malignant potential. More cases need be studied.