Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial

• DOI: 10.1186/s40814-022-01073-5
• Publication Date: 2022-06-11T08:02:56Z
• Authors: Gogem Topcu; Laura Smith; Jacqueline R. Mhi...; Nia Goulden; Zoë Hoare; Avril Drummond; Deborah Fitzsimmons; Nikos Evangelou; Klaus Schmierer; Emma C. Tallantyre; Paul Leighton; Kimberley Allen-P...; Andrea Stennett; Paul Bradley; Clare Bale; James Turton; Roshan das Nair
• Keywords: Cognitive rehabilitation therapy

Abstract Background Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability work, and quality life. Addressing cognitive is a top 10 research priority for MS. Our ongoing has systematically developed screening management pathway (NEuRoMS) tailored MS, involving brief evaluation rehabilitation intervention. The present study aims assess the feasibility delivering will inform design definitive randomised controlled trial (RCT) investigate clinical cost-effectiveness intervention eventually guide its implementation. Methods in three parts. Part 1 involves an observational those who receive support problems, using routinely collected data. 2 two-arm, parallel group, multicentre, RCT nested fidelity evaluation. This part evaluate undertaking comparing NEuRoMS plus usual care only, amongst MS mild ( n = 60). In 3, semi-structured interviews be undertaken participants from 25), clinicians 9), providers 3) involved pathway. recruited outpatient clinics at UK National Health Service hospitals. Discussion Timely effective are urgently needed due detrimental consequences on healthcare system, wider society. based previous extant literature been co-constructed relevant stakeholders. If effective, facilitate timely identification Trial registration ISRCTN11203922 . Prospectively registered 09.02.2021.