Diurnal variation of choriocapillaris vessel flow density in normal subjects measured using optical coherence tomography angiography

• DOI: 10.1186/s40942-018-0140-0
• Publication Date: 2018-09-19T07:31:09Z
• Authors: Salman Sarwar; Muhammad Hassan; Mohamed K. Soliman; Muhammad Sohail H...; Mohammad Ali Sadiq; Rubbia Afridi; Aniruddha Agarwal; Diana V. Do; Quan Dong Nguyen; Yasir J. Sepah
• Keywords: Choroid; Diurnal temperature variation; Coefficient of variation

Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported literature. In the index study, optical coherence tomography angiography (OCTA) was used to assess diurnal subjects with no known ocular disease.Fifty eyes disease (25 subjects) were included. OCTA images acquired using AngioVue (Optovue, Fremont, CA, USA) at two different time points on a single day: 9:00 AM and 6:00 PM. Macular cube scan protocol (3 × 3 mm) centered fovea used. Automatic segmentation retinal layers performed ReVue software, which also measure VFD. Horizontal line passing through obtained by device both subfoveal choroidal thickness (CT). Linear measurement tool software CT according standardized reproducible method. Wilcoxon signed-rank test differences points. Correlation between change assessed Pearson correlation coefficient (r).The mean age 31.96 ± 11.23 years. Choriocapillaris significantly higher compared PM (P < 0.0001) 68.74 4.80% 67.57 5.41% PM, amplitude 1.17%. Mean 287.74 61.51 µm 270.06 60.73 Subfoveal 17.68 µm. Change correlated (r = 0.87, P 0.001).OCTA demonstrated significant without any being morning lower evening. Decrease evening reduction CT.