Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency

• DOI: 10.1186/s40942-022-00408-x
• Publication Date: 2022-10-01T22:02:32Z
• Authors: Nelmo V. Menezes; Cynthia S. Barros...; Roberto Salvatori; Vinicius C. Gois; Cindi G. Marinho; Carla R. P. Oliveira; Viviane C. Campos; Alécia A. Oliveir...; Hertz T. Santos-J...; Elenilde G. Santos; Enaldo V. Melo; Augusto C. N. Faro; Neima V. Oliveira; Hérika M. Gumes-F...; Gustavo B. Melo; Manuel H. Aguiar-...
• Keywords: IGHD

Abstract Background The somatotrophic axis, including hypothalamic growth hormone (GH)-releasing (GHRH), pituitary GH and circulating IGF-I, is critical for body size. However, the local production of GH/IGF-I (and IGF-II) other peptides relevant functions, such as vascular, brain, retinal function. consequences deficiency (GHD) on structure are still unclear, possibly reflecting heterogeneity patients different types assessment in previous publications. Our purpose was to assess quantitative measures vascular neural components retina subjects with severe congenital isolated GHD (IGHD). Methods A cross-sectional study carried out 25 adult IGHD age- gender-matched controls. Interview, physical examination, laboratory data, optical coherence tomography (OCT) OCT angiography (OCTA) were performed. Results revealed no difference areas nerve fiber layer average, nor superior, inferior, or nasal quadrants, between two groups. temporal quadrant (p = 0.041), disc 0.042), cup < 0.0001), well cup/disc ratio higher than rim area smaller 0.002), although normal. In OCTA, there minimum foveal thickness, central fovea, avascular zone, density any assessed area. Conclusions conclusion, does not affect retina, it associated increased this genetically homogeneous cohort.