Hsa_circ_0006837 suppresses gastric cancer cell proliferation, migration, and invasion via the modulation of miR-424-5p

• DOI: 10.1186/s41065-025-00449-w
• Publication Date: 2025-05-22T14:49:05Z
• Authors: Yanxin He; Yeyu Sun; Yinglan Zheng; Yanfang Jiang; Na Li; Wenjie Zhao; Wanhua Ren

Abstract Background The mechanism by which circRERE (hsa_circ_0006837) modulates the malignant progression of gastric cancer was investigated to identify a novel biomarker and therapeutic target for this disease. Methods Hsa_circ_0006837 expression in GC tissues cells detected RT-qPCR. Several data analysis methods were used evaluate significance dysregulated hsa_circ_0006837 GC. patients followed up five years, survival conducted using Kaplan-Meier curves. Cox regression subsequently performed analyze risk factors prognosis. behaviors CCK-8 Transwell assays. relationship between miR-424-5p assessed conducting Spearman correlation verified dual-luciferase reporter assay. Results decreased with GC, indicating poorer patient In cells, overexpression suppressed behaviors. Mechanistically, identified as hsa_circ_0006837. partially counteracted suppressive effects upregulated on cells. FBXO21 downstream gene hsa_circ_0006837/miR-424-5p axis. Conclusions To summarize, is prognosis can modulate through miR-424-5p.