47Sc as useful β–-emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes

• DOI: 10.1186/s41181-017-0024-x
• Publication Date: 2017-06-02T07:34:54Z
• Authors: Katharina A. Domn...; Cristina Müller; Martina Benešová; Rugard Dressler; Stephanie Haller; Ulli Köster; Bernard Ponsard; Roger Schibli; Andreas Türler; Nicholas P. van d...
• Keywords: Neutron capture

Radiotheragnostics makes use of the same molecular targeting vectors, labeled either with a diagnostic or therapeutic radionuclide, ideally chemical element. The matched pair scandium radionuclides, 44Sc and 47Sc, satisfies desired physical aspects for PET imaging radionuclide therapy, respectively. While production application was extensively studied, 47Sc is still in its infancy. aim present study was, therefore, to investigate compare two different methods production, based on neutron irradiation enriched 46Ca 47Ti targets, produced by thermal targets via 46Ca(n,γ)47Ca → nuclear reaction fast 47Ti(n,p)47Sc reaction, product compared regard yield radionuclidic purity. separation optimized order obtain sufficient quality determined labeling experiments using DOTANOC. Finally, preclinical SPECT/CT were performed tumor-bearing mice image counterpart. Up 2 GBq targets. isolation from target material allowed formulation up 1.5 high purity (>99.99%) small volume (~700 μL) useful purposes. Three consecutive separations possible isolating in-grown 46/47Ca-containing fraction. irradiated resulted reduced (99.95–88.5%). separated radiolabeling DOTANOC achievable at specific activities 10 MBq/nmol. In vivo 47Sc-DOTANOC equal 44Sc-DOTANOC as imaging. demonstrated significant advantages over route, it provided higher quantities radionuclidically pure product. subsequent decay 47Ca enabled repeated daughter nuclide parent nuclide. Based results obtained this work, shows potential be suitable clinical application.